GLOMERULOMEGALY AND PROTEINURIA IN A PATIENT WITH IDIOPATHIC PULMONARY-HYPERTENSION

Glomerulomegaly is a histologic finding present in idiopathic pulmonar y hypertension, congenital cyanotic heart disease, morbid obesity asso ciated with sleep apnea syndrome, sickle cell disease, and polycythemi c states. This study examines the case of a 34-yr-old woman with idiop athic pulmonary artery hypertension who presented with nephrotic-range proteinuria. Kidney biopsy revealed enlarged glomeruli with mesangial -proliferative glomerulonephritis. A review of the pertinent literatur e and a discussion of the proposed pathophysiologic mechanisms leading to glomerulomegaly are presented.