CRYSTAL-STRUCTURE AND CHARACTERIZATION OF THE BISMUTH(III) COMPOUND WITH QUINOLONE FAMILY MEMBER (CIPROFLOXACIN) - ANTIBACTERIAL STUDY

Two bismuth(III) compounds of ciprofloxacin (cf) were synthesized. The crystal structure of one--(cfH(2))(cfH)[BiCl6].1H(2)O (cfH(2) = doubl y protonated molecule of cf, cfH = protonated molecule of cf)--is pres ented and discussed. The compound crystallizes in the monoclinic space group P (2)1/c with a = 17.758(4), b = 7.600(10), c = 31.908(6) Angst rom, beta = 101.03(2)degrees, Z = 4. The charge of the isolated hexach lorobismuthate(III) anions is compensated with protonated cf molecules (ionic interactions). One of the cf molecules is protonated at carbon yl oxygen O(1) and nitrogen N(24) of the piperazine residue, and the o ther at N(24) only. Two water molecules participate in the hydrogen bo nd network. Antimicrobial activity of this compound was tested against different microorganisms. The results of TG and FT-IR measurements ar e also included. (C) 1997 Elsevier Science Inc.