SYNTHESIS AND SAR OF 4-(1H-BENZIMIDAZOLE-2-CARBONYL)PIPERIDIN WITH DUAL HISTAMINE H1 TACHYKININ NK1 RECEPTOR ANTAGONIST ACTIVITY/

Authors
MAYNARD GD BRATTON LD KANE JM BURKHOLDER TP SANTIAGO R STEWART KT KUDLACZ EM SHATZER SA KNIPPENBERG RW FARRELL AM LOGAN DE
Citation
Gd. Maynard et al., SYNTHESIS AND SAR OF 4-(1H-BENZIMIDAZOLE-2-CARBONYL)PIPERIDIN WITH DUAL HISTAMINE H1 TACHYKININ NK1 RECEPTOR ANTAGONIST ACTIVITY/, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2819-2824
Citations number
10
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
22
Year of publication
1997
Pages
2819 - 2824
Database
ISI
SICI code
0960-894X(1997)7:22<2819:SASO4W>2.0.ZU;2-#
Abstract
A series of 4-(1H-benzimidazole-2-carbonyl)piperidines with dual hista mine H-1/tachykinin NK1 receptor antagonist activity has been prepared , Factors affecting receptor binding affinities and oral activity in t his series are described. (C) 1997 Elsevier Science Ltd.