FIRST TOTAL SYNTHESIS OF THE BONE-RESORPTION MARKERS DEOXYPYRIDINOLINE AND HYDROXYPYRIDINOLINE

Authors
WAELCHLI R BEERLI C MEIGEL H REVESZ L
Citation
R. Waelchli et al., FIRST TOTAL SYNTHESIS OF THE BONE-RESORPTION MARKERS DEOXYPYRIDINOLINE AND HYDROXYPYRIDINOLINE, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2831-2836
Citations number
7
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
22
Year of publication
1997
Pages
2831 - 2836
Database
ISI
SICI code
0960-894X(1997)7:22<2831:FTSOTB>2.0.ZU;2-W
Abstract
The first total synthesis of the collagen crosslinks deoxypyridinoline 1 and hydroxypyridinoline 2 was achieved. The key intermediate, pyrid ine 3 served as starting material for the preparation of compounds 1 a nd 2 and derivatives of 1. These compounds create optimal tools to est ablish a diagnostic kit for bone resorption. (C) 1997 Elsevier Science Ltd.