OLIGONUCLEOTIDES WITH (N-THYMIN-1-YLACETYL) 1-PHENYLSERINOL IN BACKBONE - CHIRAL ACYCLIC ANALOGS THAT FORM DNA TRIPLEXES

The synthesis of oligonucleotides containing chiral acyclic in-1-ylace tyl)-amino-1(R/S)-phenyl-1,3-propanediol unit in the backbone (I, R=Ar ) is described. When used as third strand of a triplex with complement ary natural duplex, the modified oligonucleotides form stable triplexe s with triplex double left right arrow duplex transition Tm dependent on the number, position and stereochemistry of modification. (C) 1997 Elsevier Science Ltd.