SYNTHESIS AND ANTI-THROMBIN ACTIVITY OF A HEXASACCHARIDE CORRESPONDING TO THE BINDING-SITE OF DERMATAN SULFATE TO HEPARIN-COFACTOR-II

Authors
BOURHIS P MACHETTO F DUCHAUSSOY P HERAULT JP MALLET JM HERBERT JM PETITOU M SINAY P
Citation
P. Bourhis et al., SYNTHESIS AND ANTI-THROMBIN ACTIVITY OF A HEXASACCHARIDE CORRESPONDING TO THE BINDING-SITE OF DERMATAN SULFATE TO HEPARIN-COFACTOR-II, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2843-2846
Citations number
18
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
22
Year of publication
1997
Pages
2843 - 2846
Database
ISI
SICI code
0960-894X(1997)7:22<2843:SAAAOA>2.0.ZU;2-S
Abstract
A new synthetic route is described toward the hexasaccharide represent ing the heparin cofactor II binding region of dermatan sulfate, The an ti-thrombin activity of this synthetic hexasaccharide is reported here for the first time, This compound is about mio hundred times less act ive than dermatan sulfate itself for its ability to inhibit thrombin v ia heparin cofactor II. (C) 1997 Published by Elsevier Science Ltd.