SYNTHESIS OF TRIMETHYLATED PHOSPHONIUM AND ARSONIUM ANALOGS OF THE OSMOPROTECTANT GLYCINE BETAINE - CONTRASTED BIOLOGICAL-ACTIVITIES IN 2 BACTERIAL SPECIES

Authors
PICHEREAU V COSQUER A GAUMONT AC BERNARD T
Citation
V. Pichereau et al., SYNTHESIS OF TRIMETHYLATED PHOSPHONIUM AND ARSONIUM ANALOGS OF THE OSMOPROTECTANT GLYCINE BETAINE - CONTRASTED BIOLOGICAL-ACTIVITIES IN 2 BACTERIAL SPECIES, Bioorganic & medicinal chemistry letters, 7(22), 1997, pp. 2893-2896
Citations number
13
Journal title
Bioorganic & medicinal chemistry letters → ACNP
ISSN journal
0960894X
Volume
7
Issue
22
Year of publication
1997
Pages
2893 - 2896
Database
ISI
SICI code
0960-894X(1997)7:22<2893:SOTPAA>2.0.ZU;2-W
Abstract
Phosphoniobetaine and arsenobetaine, the P and As analogues of glycine betaine (trimethylammonioacetate) were synthesized and assayed for ac tivity in bacterial osmoprotection biotests, using Escherichia coli an d Rhizobium meliloti as model organisms. The P- and As-betaines displa yed similar osmoprotective activities in E. coli, but were highly toxi c in the betaine-demethylating bacterium R. meliloti. (C) 1997 Elsevie r Science Ltd.