EFFECT OF COPPER(II) ON THE AEROBIC OXIDATIVE UPTAKE OF IRON(II) BY HORSE SPLEEN APOFERRITIN

Authors
MCKNIGHT J WHITE N MOORE GR
Citation
J. Mcknight et al., EFFECT OF COPPER(II) ON THE AEROBIC OXIDATIVE UPTAKE OF IRON(II) BY HORSE SPLEEN APOFERRITIN, Journal of the Chemical Society. Dalton transactions, (21), 1997, pp. 4043-4045
Citations number
34
Journal title
Journal of the Chemical Society. Dalton transactions → ACNP
ISSN journal
03009246
Issue
21
Year of publication
1997
Pages
4043 - 4045
Database
ISI
SICI code
0300-9246(1997):21<4043:EOCOTA>2.0.ZU;2-L
Abstract
The interaction of copper(II) with horse spleen apoferritin has been i nvestigated and approximately 16-22 Cu-II ions are shown to bind relat ively tightly to the 24 subunit protein. The bound Cu-II is shown to h ave a catalytic effect on the aerobic oxidative uptake of Fe-II rather than the inhibitory effect that Zn-II has. Possible reasons for this are discussed.