OXIDATIVE DAMAGE ON RNA MEDIATED BY CATIONIC METALLOPORPHYRIN ANTISENSE OLIGONUCLEOTIDES CONJUGATES

Authors
DUARTE V SIXOU S FAVRE G PRATVIEL G MEUNIER B
Citation
V. Duarte et al., OXIDATIVE DAMAGE ON RNA MEDIATED BY CATIONIC METALLOPORPHYRIN ANTISENSE OLIGONUCLEOTIDES CONJUGATES, Journal of the Chemical Society. Dalton transactions, (21), 1997, pp. 4113-4118
Citations number
27
Journal title
Journal of the Chemical Society. Dalton transactions → ACNP
ISSN journal
03009246
Issue
21
Year of publication
1997
Pages
4113 - 4118
Database
ISI
SICI code
0300-9246(1997):21<4113:ODORMB>2.0.ZU;2-Z
Abstract
A manganese cationic porphyrin covalently linked to the 5' end of an a ntisense oligonucleotide was shown to mediate sequence-specific oxidat ive lesions on a mRNA target when activated by KHSO5. This manganese p orphyrin cleaver did not induce direct RNA strand breaks but promoted the arrest of reverse transcription due to oxidative damage on bases o f the RNA template.