This work presents a simulation application study on the design of cen
tralized PI controllers for a MSF desalination plant. Various design m
ethods based on the transfer function matrix of the plant are consider
ed. The methods include (1) the Davison method, (2) the Maciejowski me
thod, (3) the decoupler design and (4) the Tanttu and Lieslehto method
. The performance of the closed loop system for a step change in the s
et point is compared. The robustness of the controlled system for unce
rtainties in the system steady-state gains is also evaluated.