The structures of two absorption furosemide prodrugs, hexanoyloxymethyl 4-c
hloro-N-furfuryl-5-sulfamoylanthranilate (C19H23ClN2O7S), (I), and benzoylo
xymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate (C20H17ClN2O7S), (II),
are described in this paper and compared with furosemide and four other pr
odrugs, The molecular conformations of both compounds are similar to those
of the other prodrugs; the packing and the crystal system are the primary d
ifferences. Compound (I) crystallizes in the trigonal space group <R(3)over
bar> and compound (II) in the monoclinic space group P2(1)/n. The packing
of both structures is stabilized by a three-dimensional hydrogen-bond netwo
rk.