Two absorption furosemide prodrugs

The structures of two absorption furosemide prodrugs, hexanoyloxymethyl 4-c hloro-N-furfuryl-5-sulfamoylanthranilate (C19H23ClN2O7S), (I), and benzoylo xymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate (C20H17ClN2O7S), (II), are described in this paper and compared with furosemide and four other pr odrugs, The molecular conformations of both compounds are similar to those of the other prodrugs; the packing and the crystal system are the primary d ifferences. Compound (I) crystallizes in the trigonal space group <R(3)over bar> and compound (II) in the monoclinic space group P2(1)/n. The packing of both structures is stabilized by a three-dimensional hydrogen-bond netwo rk.