Two absorption furosemide prodrugs

Citation
Aw. Mombru et al., Two absorption furosemide prodrugs, ACT CRYST C, 55, 1999, pp. 413-416
Citations number
10
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
55
Year of publication
1999
Part
3
Pages
413 - 416
Database
ISI
SICI code
0108-2701(19990315)55:<413:TAFP>2.0.ZU;2-E
Abstract
The structures of two absorption furosemide prodrugs, hexanoyloxymethyl 4-c hloro-N-furfuryl-5-sulfamoylanthranilate (C19H23ClN2O7S), (I), and benzoylo xymethyl 4-chloro-N-furfuryl-5-sulfamoylanthranilate (C20H17ClN2O7S), (II), are described in this paper and compared with furosemide and four other pr odrugs, The molecular conformations of both compounds are similar to those of the other prodrugs; the packing and the crystal system are the primary d ifferences. Compound (I) crystallizes in the trigonal space group <R(3)over bar> and compound (II) in the monoclinic space group P2(1)/n. The packing of both structures is stabilized by a three-dimensional hydrogen-bond netwo rk.