Equilin

Authors
Sawicki, MW Li, NY Ghosh, D
Citation
Mw. Sawicki et al., Equilin, ACT CRYST C, 55, 1999, pp. 425-427
Citations number
14
Categorie Soggetti
Physical Chemistry/Chemical Physics
Journal title
ACTA CRYSTALLOGRAPHICA SECTION C-CRYSTAL STRUCTURE COMMUNICATIONS
ISSN journal
01082701 → ACNP
Volume
55
Year of publication
1999
Part
3
Pages
425 - 427
Database
ISI
SICI code
0108-2701(19990315)55:<425:E>2.0.ZU;2-P
Abstract
3-Hydroxyestra-1,3,5(10),7-tetraen-17-one, C18H20O2, crystallizes in space group P2(1)2(1)2(1) from ethyl acetate. The planarity of the B ring, and th e difference in puckering of the C and D rings from that of estrone, are du e to the presence of the C7=C8 double bond, which may explain its function as an inhibitor of human type 1 17 beta-hydroxysteroid dehydrogenase, inste ad of being its substrate.