Mixed allogeneic chimerism to induce tolerance to solid organ and cellulargrafts

Transplantation of solid organs and cellular grafts has become clinical rou tine in the last 30 years, However, the requirement for life-long immunosup pression is associated with infections, malignancies and end-organ toxicity . Moreover, the treatment fails to prevent ch ron ic rejection. The inducti on of donor-specific transplantation tolerance would solve these problems, but has remained an elusive goal. One approach to achieve transplantation t olerance is through hematopoietic chimerism. This review outlines different concepts of hematopoietic chimerism focusing on macrochimerism. Mixed allo geneic chimerism, also known as macrochimerism, is defined as engraftment o f hematopoietic stem cells achieved by bone marrow transplantation (BMT), I t discusses the advantages and limitations of the BMT as well as approaches to overcome these limitations in the future.