Gamma camera imaging of platinum in tumours and tissues of patients after administration of Pt-191-cisplatin

The aim of this study was to visualize non-invasively the uptake of platinu m in tumours and tissues after treatment with cisplatin. Pt-191-cisplatin w as synthesized from (PtCl4)-Pt-191, With rigorous pharmaceutical quality co ntrol. The uptake of platinum by both tumorous and healthy tissues was stud ied by gamma camera imaging in 14 patients, 5 of whom showed a clear uptake of platinum in regions corresponding to known tumour sites. Maximum concen trations of platinum in the tumours were on average 4.9 +/- 1.0 mu g/g, whe n normalized to an administered amount of 180 mg cisplatin. In all the pati ents, the liver was the organ that showed the highest uptake. Platinum upta ke was also seen in the spleen, gall bladder, gastrointestinal tract, bladd er, kidneys, ureter, neck and mediastinum and urogenital region. By using i n-house production of and healthy organs. Pt-191-cisplatin, it was possible to monitor the uptake of platinum in tumorous tissues and healthy organs.