Serendipitous rapid detoxification from opiates: the importance of time-dependent processes

Opiate detoxification procedures aim to reduce intensity and duration of wi thdrawal. Ultra-rapid opiate detoxification (UROD) methods attempt to obtai n this goal by administering naltrexone under deep sedation or anaesthesia. We present a case study on accidental ingestion of naltrexone in a methado ne maintenance patient, which shows close methodological similarities with UROD procedures. Naltrexone was effective in reducing withdrawal duration, but not as much as UROD studies report. The administration of naloxone afte r detoxification did not trigger withdrawal symptoms, even in the presence of methadone, as detected by urinalyses. These results suggest the importan ce of further developing detoxification methods based on protocols of admin istration of antagonists different from UROD, in absence of anaesthesia.