Jm. Burns et al., Lifetime low-level exposure to environmental lead and children's emotionaland behavioral development at ages 11-13 years - The Port Pirie Cohort Study, AM J EPIDEM, 149(8), 1999, pp. 740-749
Citations number
51
Categorie Soggetti
Envirnomentale Medicine & Public Health","Medical Research General Topics
The Port Pirie Cohort Study is the first study to monitor prospectively the
association between lifetime blood lead exposure and the prevalence of emo
tional and behavioral problems experienced by children. Lead exposure data
along with ratings on the Child Behavior Checklist were obtained for 322 11
-13-year-old children from the lead smelting community of Port Pirie, Austr
alia. Mean total behavior problem score (95% confidence interval (CI)) for
boys whose lifetime average blood lead concentration was above 15 mu g/dl w
as 28.7 (24.6-32.8) compared with 21.1 (17.5-24.8) in boys with lower expos
ure levels. The corresponding mean scores (95% CI) for girls were 29.7 (25.
3-34.2) and 18.0 (14.7-21.3), After controlling for a number of confounding
variables, including the quality of the child's HOME environment (assessed
by Home Observation for Measurement of the Environment), maternal psychopa
thology, and the child's IQ, regression modeling predicted that for a hypot
hetical increase in lifetime blood lead exposure from 10 to 30 mu g/dl, the
externalizing behavior problem score would increase by 3.5 in boys (95% CI
1.6-5.4), and by 1.8 (95% CI -0.1 to 11.1) in girls. Internalizing behavio
r problem scores were predicted to rise by 2.1 (95% CI 0.0-4.2) in girls bu
t by only 0.8 (95% CI -0.9 to 2.4) in boys.