Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy-esterification of a resin-bound alcohol

Authors
Hammond, J Kellam, B Moffat, AC Jee, RD
Citation
J. Hammond et al., Non-destructive real-time reaction monitoring in solid phase synthesis by near-infrared reflectance spectroscopy-esterification of a resin-bound alcohol, ANAL COMMUN, 36(4), 1999, pp. 127-129
Citations number
18
Categorie Soggetti
Spectroscopy /Instrumentation/Analytical Sciences
Journal title
ANALYTICAL COMMUNICATIONS
ISSN journal
13597337 → ACNP
Volume
36
Issue
4
Year of publication
1999
Pages
127 - 129
Database
ISI
SICI code
1359-7337(199904)36:4<127:NRRMIS>2.0.ZU;2-J
Abstract
Near-infrared (NIR) reflectance spectroscopy has been used to monitor the c hemical inter-conversion of resin-bound functional groups. Measurements req uired no sample preparation and were made directly through the bottom of th e glass reaction vessel. The time-concentration profile of the esterificati on of a resin-bound alcohol by acetic anhydride in a toluene medium is demo nstrated.