K. Murai et al., Removal of cartilage rings of the graft and omentopexy for extended tracheal autotransplantation, ANN THORAC, 67(3), 1999, pp. 776-780
Citations number
15
Categorie Soggetti
Cardiovascular & Respiratory Systems","Medical Research Diagnosis & Treatment
Background. One of the serious problems in longer-size tracheal transplanta
tion is infection or severe stenosis of the graft, probably caused by an in
adequate blood supply even with omentopexy. For obtaining an appropriate bl
ood supply, we experimentally developed a new technique that included remov
al of some cartilage rings of the graft and omentopexy.
Methods. Twenty-one adult mongrel dogs were used. In group A (n = 11), a ni
ne-cartilage ring length of the trachea in which six of nine rings were rem
oved, leaving one cartilage ring at each end of the graft and another in th
e center, was autotransplanted with omentopexy. Two artificial tracheal rin
gs outside the graft were used for maintaining the lumen. In group B (n = 1
0), a nine-cartilage ring length of the trachea was autotransplanted with o
mentopexy.
Results. In group A, all dogs survived until being sacrificed, whereas 5 gr
oup B dogs died of graft infection and mediastinitis (p < 0.05 versus group
A). Mucosal blood now of the graft in group A was normal and higher than i
n group B (p < 0.05). Grade of the graft stenosis at death or sacrifice was
14% +/- 1% in group A and 58% +/- 25% in group B (p < 0.05).
Conclusions. Removal of some cartilage rings improved blood supply to the g
raft and resulted in satisfactory survival and nonsignificant tracheal sten
osis in extended tracheal autotransplantation.