Basic research into the prevalence, natural course, and phenomena of comorb
idity of depressive disorders during childhood are reviewed and implication
s of this research for treating depressed youths are noted. Results of inve
stigations into the biological aspects of depression are integrated into a
multifactorial model of depressive disorders during childhood and the effic
acy of pharmacological interventions is discussed. Cognitive theory is inte
grated with attachment theory to explain a possible avenue to the developme
nt of depressive disorders during childhood. Interpersonal therapy has emer
ged as a potentially effective intervention for depressed youths. Basic ten
ets of this treatment model are compared and contrasted to a cognitive-beha
vioral treatment model, and a hybrid treatment referred to as "cognitive th
erapy within the interpersonal context" is proposed.