A new cytotoxic acyclic diterpene from Carpesium divaricatum

Authors
Zee, OP Kim, DK Choi, SU Lee, CO Lee, KR
Citation
Op. Zee et al., A new cytotoxic acyclic diterpene from Carpesium divaricatum, ARCH PH RES, 22(2), 1999, pp. 225-227
Citations number
5
Categorie Soggetti
Pharmacology & Toxicology
Journal title
ARCHIVES OF PHARMACAL RESEARCH
ISSN journal
02536269 → ACNP
Volume
22
Issue
2
Year of publication
1999
Pages
225 - 227
Database
ISI
SICI code
0253-6269(199904)22:2<225:ANCADF>2.0.ZU;2-G
Abstract
A new acyclic diterpene (1) and a known acyclic diterpene, 12(S)-hydroxyger anylgeraniol (2) were isolated from the aerial parts of Carpesium divaricat um. The structure of 1 was determined to be (2E,10E)-1, 12-dihydroxy-18-ace toxy-3,7,15-trimethylhexadeca-2,10,14-triene (1) on the basis of spectrosco pic studies. Compounds 1 and 2 exhibited cytotoxicity against cultured huma n tumor cell lines, A549, SK-OV-3, SK-MEL-2, XF498, and HCT15, with ED50 va lues ranging from 4.3-10.2 mu g/ml and 4.1-8.3 mu g/ml, respectively.