CHARACTERIZATION OF RISKS ASSOCIATED WITH THE USE OF MOLINATE

A review of the toxicological information indicated that the most crit ical/sensitive toxicological endpoints of concern for human exposure t o molinate, a thiocarbamate, preemergent herbicide, were adverse repro ductive effects, neurotoxicity, and possible oncogenicity. Occupationa l and nonoccupational exposures to molinate potentially involved oral, dermal, and inhalation routes. Margins of safety for potential short- term, seasonal, annual, and lifetime exposures to workers associated w ith handling and application of molinate, the general public, and farm ers were greater than the values conventionally recommended to protect people from the toxic effects of a chemical. (C) 1997 Academic Press.