A review of the toxicological information indicated that the most crit
ical/sensitive toxicological endpoints of concern for human exposure t
o molinate, a thiocarbamate, preemergent herbicide, were adverse repro
ductive effects, neurotoxicity, and possible oncogenicity. Occupationa
l and nonoccupational exposures to molinate potentially involved oral,
dermal, and inhalation routes. Margins of safety for potential short-
term, seasonal, annual, and lifetime exposures to workers associated w
ith handling and application of molinate, the general public, and farm
ers were greater than the values conventionally recommended to protect
people from the toxic effects of a chemical. (C) 1997 Academic Press.