CHARACTERIZATION OF RISKS ASSOCIATED WITH THE USE OF MOLINATE

Citation
Rc. Cochran et al., CHARACTERIZATION OF RISKS ASSOCIATED WITH THE USE OF MOLINATE, Regulatory toxicology and pharmacology, 25(2), 1997, pp. 146-157
Citations number
74
Categorie Soggetti
Medicine, Legal","Pharmacology & Pharmacy",Toxicology
ISSN journal
02732300
Volume
25
Issue
2
Year of publication
1997
Pages
146 - 157
Database
ISI
SICI code
0273-2300(1997)25:2<146:CORAWT>2.0.ZU;2-H
Abstract
A review of the toxicological information indicated that the most crit ical/sensitive toxicological endpoints of concern for human exposure t o molinate, a thiocarbamate, preemergent herbicide, were adverse repro ductive effects, neurotoxicity, and possible oncogenicity. Occupationa l and nonoccupational exposures to molinate potentially involved oral, dermal, and inhalation routes. Margins of safety for potential short- term, seasonal, annual, and lifetime exposures to workers associated w ith handling and application of molinate, the general public, and farm ers were greater than the values conventionally recommended to protect people from the toxic effects of a chemical. (C) 1997 Academic Press.