Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors

Authors
Bachand, B DiMaio, J Siddiqui, MA
Citation
B. Bachand et al., Synthesis and structure-activity relationship of potent bicyclic lactam thrombin inhibitors, BIOORG MED, 9(7), 1999, pp. 913-918
Citations number
7
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
913 - 918
Database
ISI
SICI code
0960-894X(19990405)9:7<913:SASROP>2.0.ZU;2-T
Abstract
A simple and versatile method for preparation of (D)-Phe-Pro peptidomimetic bicyclic thiazolidine lactams is presented. These bicyclic lactams have ch emical diversity alpha to the lactam carbonyl and, when linked to electroph ilic arginines, provide potent thrombin inhibitors. (C) 1999 Elsevier Scien ce Ltd. All rights reserved.