Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase:Identification of alpha v beta 3 antagonists lead compounds

Authors
Rockwell, AL Rafalski, M Pitts, WJ Batt, DG Petraitis, JJ DeGrado, WF Mousa, S Jadhav, PK
Citation
Al. Rockwell et al., Rapid synthesis of RGD mimetics with isoxazoline scaffolds on solid phase:Identification of alpha v beta 3 antagonists lead compounds, BIOORG MED, 9(7), 1999, pp. 937-942
Citations number
19
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
937 - 942
Database
ISI
SICI code
0960-894X(19990405)9:7<937:RSORMW>2.0.ZU;2-P
Abstract
Isoxazoline containing RGD mimetics were rapidly synthesized on a solid pha se to optimize linkers, regioisomers of isoxazoline scaffolds, and exosite binding groups to yield lead alpha v beta 3 antagonists. (C) 1999 DuPont Ph armaceuticals. Published by Elsevier Science Ltd. All rights reserved.