Discovery of a novel series of selective MMP inhibitors: Identification ofthe gamma-sulfone-thiols

Authors
Freskos, JN Mischke, BV DeCrescenzo, GA Heintz, R Getman, DP Howard, SC Kishore, NN McDonald, JJ Munie, GE Rangwala, S Swearingen, CA Voliva, C Welsch, DJ
Citation
Jn. Freskos et al., Discovery of a novel series of selective MMP inhibitors: Identification ofthe gamma-sulfone-thiols, BIOORG MED, 9(7), 1999, pp. 943-948
Citations number
16
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
943 - 948
Database
ISI
SICI code
0960-894X(19990405)9:7<943:DOANSO>2.0.ZU;2-M
Abstract
We have discovered a new series of potent MMP Inhibitors that are selective for MMP-13 over MMP-1 incorporating a gamma-sulfone thiol. (C) 1999 Elsevi er Science Ltd. All rights reserved.