4-phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice

Authors
Yamaguchi, K Yada, M Tsuji, T Hatanaka, Y Goda, K Kobori, T
Citation
K. Yamaguchi et al., 4-phenylthiazole derivatives inhibit IL-6 secretion in osteoblastic cells and suppress bone weight loss in ovariectomized mice, BIOORG MED, 9(7), 1999, pp. 957-960
Citations number
9
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
957 - 960
Database
ISI
SICI code
0960-894X(19990405)9:7<957:4DIISI>2.0.ZU;2-8
Abstract
A series of 4-phenylthiazole derivatives were synthesized and tested their inhibitory effect on the interleukin-6 secretion stimulated by PTH in osteo blastic cells. SCRC2941-18, 2 amino-4-(4-chlorophenyl)-5-methylthiazole, wa s found to be the most potent inhibitor in the derivatives. Furthermore, SC RC2941-18 significantly suppressed the bone weight loss in the ovariectomiz ed mice, an osteoporosis model, (C) 1999 Elsevier Science Ltd. All rights r eserved.