Solid phase synthesis of structurally diverse pyrimido[4,5-d] pyrimidines for the potential use in combinatorial chemistry

An efficient solid phase synthesis of pyrinido[4,5-d]pyrimidine derivatives is described. Reaction of polymer-bound pyrimidine 1 with urea or thiouea followed by cleavage from the support provided 4-aminopyrimido[4,5-d]pyrimi dines 4 and 5 while treatment of 6 with phenyl isocyanate or phenyl isothio cyanate followed by cleavage from resin afforded 3-phenylpyrimido[4,5-d]pyr imidines 9 and 10. (C) 1999 Elsevier Science Ltd. All rights reserved. All rights reserved.