Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole aspotential antibacterial agents.

Authors
Antolini, M Bozzoli, A Ghiron, C Kennedy, G Rossi, T Ursini, A
Citation
M. Antolini et al., Analogues of 4,5-bis(3,5-dichlorophenyl)-2-trifluoromethyl-1H-imidazole aspotential antibacterial agents., BIOORG MED, 9(7), 1999, pp. 1023-1028
Citations number
14
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
1023 - 1028
Database
ISI
SICI code
0960-894X(19990405)9:7<1023:AO4A>2.0.ZU;2-G
Abstract
A preliminary exploration of analogues of 4,5-bis(3,5-dichlorophenyl)-2-tri fluoromethyl-1H-imidazole, 1, as novel antibacterial agents was carried out to determine the basic features of the structure responsible for the obser ved biological activity. The presence of two aryl rings, the imidazole NH a nd either a good electron withdrawing group or an aldehyde or amino group a t C-2 were required for good levels of activity against methicillin resista nt Staphylococcus aureus (MRSA). (C) 1999 Elsevier Science Ltd. All rights reserved.