Total synthesis of an antioxidant isolated from yeast via palladium-catalyzed coupling and its application for related compounds

Authors
Jinno, S Okita, T Inouye, K
Citation
S. Jinno et al., Total synthesis of an antioxidant isolated from yeast via palladium-catalyzed coupling and its application for related compounds, BIOORG MED, 9(7), 1999, pp. 1029-1032
Citations number
12
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
1029 - 1032
Database
ISI
SICI code
0960-894X(19990405)9:7<1029:TSOAAI>2.0.ZU;2-6
Abstract
A total synthesis of an antioxidant (1) having a benzofuran skeleton was ac hieved in four steps via the palladium(0)-catalyzed cross-coupling reaction . We also prepared several related compounds bearing a variety of aromatic or heterocyclic rings. Some of these compounds demonstrate more potent than 1 for antioxidative activity using guinea pig liver microsomes. (C) 1999 E lsevier Science Ltd. All rights reserved.