4-aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists

Authors
Cocuzza, AJ Hobbs, FW Arnold, CR Chidester, DR Yarem, JA Culp, S Fitzgerald, L Gilligan, PJ
Citation
Aj. Cocuzza et al., 4-aryl-2-anilinopyrimidines as corticotropin-releasing hormone (CRH) antagonists, BIOORG MED, 9(7), 1999, pp. 1057-1062
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
1057 - 1062
Database
ISI
SICI code
0960-894X(19990405)9:7<1057:4ACH(A>2.0.ZU;2-U
Abstract
A series of 4-aryl-2-(N-ethylanilino)pyrimidines has been synthesized as co rticotropin-releasing hormone (CRH) inhibitors. The effect of substitution on each aromatic ring on receptor binding was investigated. (C) 1999 DuPont Pharmaceuticals. Published by Elsevier Science Ltd. All rights reserved.