Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists

Authors
Cocuzza, AJ Chidester, DR Culp, S Fitzgerald, L Gilligan, P
Citation
Aj. Cocuzza et al., Use of the Suzuki reaction for the synthesis of aryl-substituted heterocycles as corticotropin-releasing hormone (CRH) antagonists, BIOORG MED, 9(7), 1999, pp. 1063-1066
Citations number
15
Categorie Soggetti
Chemistry & Analysis
Journal title
BIOORGANIC & MEDICINAL CHEMISTRY LETTERS
ISSN journal
0960894X → ACNP
Volume
9
Issue
7
Year of publication
1999
Pages
1063 - 1066
Database
ISI
SICI code
0960-894X(19990405)9:7<1063:UOTSRF>2.0.ZU;2-I
Abstract
The Suzuki reaction has been used to synthesize a variety of aryl-substitut ed heterocyclic antagonists of the CRH1 receptor. Examples with several dif ferent heterocyclic cores are potent CRH receptor ligands. (C) 1999 (C) 199 9 DuPont Pharmaceuticals. Published by Elsevier Science Ltd. All rights res erved.