Wr. Cullen et al., THE EFFECT OF ORGANOTIN COMPOUNDS ON THE PERMEABILITY OF MODEL BIOLOGICAL-MEMBRANES, Applied organometallic chemistry, 11(5), 1997, pp. 369-379
The efflux of dimethylarsinic acid (DMA) from liposomes formed from eg
g phosphatidylcholine (EPC) is increased when tributyltin chloride (TB
T) is added to the extraliposomal compartment; however the addition of
monobutyltin trichloride (MBT) slows down the efflux. When the liposo
mes are prepared from EPC and organotin compounds, different mechanism
s for DMA efflux seem to operate: TBT-EPC liposomes show a mixture of
facilitated and passive diffusion; MBT-EPC liposomes show only passive
diffusion. The facilitated diffusion of DMA(-) seems to be stopped by
the addition of TBT to the extraliposomal compartment. (C) 1997 by Jo
hn Wiley & Sons, Ltd.