Neurologic manifestations of Lyme disease are common in children, amon
g whom the incidence of Lyme disease is higher than among adults. Cran
ioneuropathies, in particular palsy of the facial nerve, occur in appr
oximately 3-5% of children with Lyme disease, followed in frequency by
meningitis (1% of symptomatic children). Children with only non-speci
fic symptoms such as headache, arthralgia or fatigue commonly are misd
iagnosed as having Lyme disease. Although such non-specific symptoms o
ften accompany more specific signs and symptoms (e.g., erythema migran
s, arthritis) in children with Lyme disease, very rarely are non-speci
fic symptoms the sole manifestation of Lyme disease. A number of caref
ully conducted follow-up studies have indicated that the prognosis is
excellent for children with Lyme disease who have been treated with st
andard antimicrobial regimens.