Leukemias and lymphomas: time trends in the UK, 1984-93

Objective: To investigate recent time trends of some selected and common ne oplasms of the blood and lymphatic tissues. Methods. A specialist population-based register of hematological and relate d neoplasms was set up in parts of the UK in 1984. Secular changes over the first 10 years were investigated using log-linear Poisson modeling. The re sults are presented in tabular and graphical form. Results: The analyses of 26,899 cases revealed a decline in incidence of ac ute myeloid leukaemia (AML), the myeloproliferative disorders (MPD) includi ng chronic myeloid leukaemia (CML) and, in males only, Hodgkin's disease (H D). No secular trends for acute lymphoblastic leukaemia (ALL) were observed at any age. A marked increase in incidence in non-Hodgkin's disease (NHL) and the pre-leukemia group of myeloid dysplasias (MDS) was found. Conclusions: The rise in MDS and decline in AML and related conditions are most likely to reflect diagnostic changes. Changes in NHL may reflect, in p art, a similar phenomena, but an underlying upward trend cannot be excluded . The decline in HD is in one gender only and the significance of this rema ins to be investigated.