Synthesis of cancer peptide antigen-lipid a analog conjugates for synthetic vaccines

Authors
Ikeda, K Miyajima, K Maruyama, Y Achiwa, K
Citation
K. Ikeda et al., Synthesis of cancer peptide antigen-lipid a analog conjugates for synthetic vaccines, CHEM PHARM, 47(4), 1999, pp. 563-568
Citations number
27
Categorie Soggetti
Chemistry & Analysis
Journal title
CHEMICAL & PHARMACEUTICAL BULLETIN
ISSN journal
00092363 → ACNP
Volume
47
Issue
4
Year of publication
1999
Pages
563 - 568
Database
ISI
SICI code
0009-2363(199904)47:4<563:SOCPAA>2.0.ZU;2-Q
Abstract
Conjugates 6 and 7 of cancer peptide antigen with N-tetradecanoyl L-serine- beta-alanine-containing D-glucosamine derivative structurally related to li pid A as an immunoadjuvant were synthesized for the development of totally synthetic vaccines against cancers, The mitogenic activities of compounds 6 and 7 were stronger than that of lipid A analog 3.