The prognostic utility of an exercise ECG test depends upon having an adequ
ate workload to stress the cardiac system. A negative stress test, in which
there are no adverse clinical or ECG findings, and in which an adequate wo
rkload is achieved, stratifies patients into a low-risk group. The 1997 Ame
rican Heart Association guidelines imply that any index of workload-heart r
ate, rate-pressure product, or exercise duration in multiples of resting O-
2 consumption (METS)-could be used to indicate that adequate stress was ach
ieved, However, while there is considerable evidence supporting the use of
METS as a strong independent prognostic variable, there is less support for
the use of rate-pressure product or heart rate. Indeed, there is evidence
that a high heart rate at a low workload carries an adverse prognosis, Furt
her research is needed to identify the number of METS achieved that would d
efine an adequate workload. In the meantime, a review of the literature sug
gests that 7 to 10 METS is a reasonable ballpark figure of the minimum work
load in patients with a negative stress test that would imply a favorable o
utcome.