Intercellular adhesion molecule-1 and accumulation of eosinophils in nasalpolyp tissue

Objective To investigate the relationship between intercellular adhesion mo lecule-1 (ICAM-1) and the accumulation of eosinophils in nasal polyp tissue to better understand the mechanism of airway eosinophilic inflammation. Methods The expression of ICAM-1 and its natural ligand, lymphocyte functio n-associated antigen-1 (LFA-1), in normal nasal mucosa from 6 controls and in nasal polyp tissue from 19 patients with nasal polyposis were determined with immunohistochemistry. With dual immunohistochemistry and May-Griunwal d Giemsa stain (MGG), the expression of LFA-1 and infiltrating eosinophils in nasal polyp tissue was observed. Results The expression of ICAM-1 and LFA-1 was stronger in the nasal polyp tissue than in normal nasal mucosa. There was a positive relationship betwe en the infiltration of eosinophils and the expression of LFA-1 on eosinophi ls. Conclusion Accumulation of eosinophils in nasal polyp tissue is associated with the counter-effect between adhesion molecules and its ligand on eosino phils.