Citation
Hj. Mauceri et al., Radiation-inducible gene therapy, CR AC S III, 322(2-3), 1999, pp. 225-228
Citations number
19
Categorie Soggetti
Multidisciplinary,"Experimental Biology
Journal title
COMPTES RENDUS DE L ACADEMIE DES SCIENCES SERIE III-SCIENCES DE LA VIE-LIFE SCIENCES
ISSN journal
07644469
→ ACNP
Volume
322
Issue
2-3
Year of publication
1999
Pages
225 - 228
Database
ISI
SICI code
0764-4469(199902/03)322:2-3<225:RGT>2.0.ZU;2-K
Abstract
The radiation-inducible chimeric genetic construct Egr-TNF alpha introduced
into human xenografts produces cytotoxicity of infected tumor cells result
ing in tumor growth inhibition. The interaction between Egr-TNF and radiati
on is selectively cytotoxic for the tumor microvasculature resulting in vas
cular thrombosis and tumor necrosis. Gene therapy combined with radiation t
herapy offers great potential for the treatment of localized human cancers.
((C) Academie des sciences / Elsevier, Paris.)