Uterine histopathologic changes after Cu-Fix intrauterine device insertion

A study of uterine histopathologic changes after the insertion of the Cu-Fi x intrauterine device (IUD) was carried out at the Obstetrics and Gynecolog y Department, Faculty of Medicine, Chulalongkorn University. Ten patients, who had cold conization for a suspicious Papanicolaou smear, were fitted wi th the Cu-Fix IUD. All patients were diagnosed as having carcinoma-in-situ of the cervix and were scheduled for hysterectomy at 6 weeks postconization . Preoperative ultrasonography showed the IUD anchoring at the uterine fund us, which corresponded with posthysterectomized findings. At the anchoring site of the nylon knot, which serves as a small retention body in the fundu s, slight mononuclear cells infiltration in the myometrium was found in onl y one patient. However, in the endometrium, there was infiltration of monon uclear cells as well as a few plasma cells during the proliferative phase o f the cycle. Evidence of local foreign body reaction was found in all patie nts. No patient had symptoms or signs of pelvic infection. (C) 1999 Elsevie r Science Inc. All rights reserved.