B. Eriksson et al., Establishment and characterization of a mouse strain (TLL) that spontaneously develops T-cell lymphomas/leukemia, EXP HEMATOL, 27(4), 1999, pp. 682-688
In this study, a mouse strain (TLL) that spontaneously develops T-cell lymp
homas/leukemia with an early onset and high incidence was established and c
haracterized. All tumors analyzed were found to express the alpha,beta T-ce
ll receptor, and the majority of them had a mature, CD3(+) CD4(+)CD8(-) imm
unophenotype. In a fea cases, tumors with a more immature CD3(+)CD4(+)CD8() phenotype were isolated. Expanded phenotyping using a broad panel of lymp
hocyte differentiation markers confirmed the mature T-cell phenotype of the
tumors. Histologic and cell cycle analysis of the tumors revealed an aggre
ssive lymphoblastic malignancy with a very high proliferation rate and wide
spread engagement of bone marrow and lymphoid as well as nonlymphoid organs
. Thus, the TLL mouse strain represents a unique model for the analysis of
the oncogenesis and progression of mature T-cell tumors and for the develop
ment of therapeutic measures to combat such tumors. (C) 1999 International
Society for Experimental Hematology, Published by Elsevier Science Inc.