Renal effects of cP450 arachidonate metabolites in the Lyon hypertensive rat

This study is aimed at evaluating the influence of the cytochrome P450 arac hidonate metabolites on the renal alterations exhibited by the Lyon hyperte nsive (LH) rat. To that purpose, kidneys were isolated from LH rats and the ir normotensive (LN) controls and single-pass perfused at different pressur e levels before (control conditions) and after cytochrome P450 inhibition b y 7-ethoxyresorufin (7-ER, 1 mu M). In control conditions, LH kidneys diffe red from LN ones by an increased preglomerular resistance and a blunted pre ssure natriuresis. 7-ER, which did not affect the function of LN kidneys, d ecreased the vascular resistance of LH kidneys, increased their glomerular filtration rate but had no effect on their pressure natriuresis. These resu lts indicate that the renal cytochrome P450 arachidonate metabolism differs between LN and LH rats and is presumably involved in the functional altera tions exhibited by LH kidneys. (C) Elsevier, Paris.