Epidemiology and type A and B hemophilia in Moscow boys in 1971-1995.

A retrospective epidemiological survey was made of hemophylia A and B incid ence rate in boys of Moscow for 1971-1995. There were 209 cases of hemophyl ia A and 54 of hemophylia B. The morbidity was estimated per 10000 neonate boys born alive. This estimate is recommended for standardisation and appli cation in RF Hemophylia Centers. No growth tendencies for prevalence of hem ophylia in Moscow boys were found. As seen by the age of diagnosis in three time subcohorts, early diagnosis of hemophylia has improved significantly: 100% of the patients with hemophylia were identified by the age 13.5, 10.5 and 3.5 years in cohorts 1980-1984, 1985-1989 and 1990-1995, respectively. 75% of the cases are now diagnosed at the age 6-12 months. Further progres s of hemophylia early diagnosis depends on the quality of medico-genetic co nsulting and introduction of molecular-genetic methods of examination.