Chromosomal mapping of five mouse G protein gamma subunits

Heterotrimeric G proteins, composed of alpha, beta, and gamma subunits, tra nsduce signals from transmembrane receptors to a wide range of intracellula r effecters. The G protein gamma subunits, which play an indispensible role in this communication, constitute a large and diverse multigene family. Us ing an interspecific back cross panel, we have determined the mouse chromos omal locations of five gamma subunit genes: gamma 2, gamma 8, gamma 10, gam ma 12, and gamma Cone. Combined with previous mapping studies, these data i ndicate that, with the possible exception of gamma 1 and gamma 11, the G pr otein gamma subunit genes are well dispersed within the mouse and human gen omes. (C) 1999 Academic Press.