The isolation and structure of pumiliotoxin 341A: A novel cyclic ether from the frog Epipedobates tricolor

Authors
Jain, P Spande, TF Garraffo, HM Daly, JW
Citation
P. Jain et al., The isolation and structure of pumiliotoxin 341A: A novel cyclic ether from the frog Epipedobates tricolor, HETEROCYCLE, 50(2), 1999, pp. 903-912
Citations number
13
Categorie Soggetti
Organic Chemistry/Polymer Science
Journal title
HETEROCYCLES
ISSN journal
03855414 → ACNP
Volume
50
Issue
2
Year of publication
1999
Pages
903 - 912
Database
ISI
SICI code
0385-5414(19990401)50:2<903:TIASOP>2.0.ZU;2-U
Abstract
An alkaloid 341A isolated by HPLC from skin extracts of the Ecuadoran poiso n frog Epipedobates tricolor was characterized by FTIR, MS and H-1-NMR spec tral analysis and assigned a spiro-fused pyranoindolizidine structure (1). It represents the first member of a small group of pumiliotoxin alkaloids t o contain a cyclic ether moiety.