Synthesis of new melatoninergic ligands including azaindole moiety

A novel series of melatonin analogues, based on the azaindole nucleus is de scribed. These compounds are prepared in several steps directly from the co mmercial available 7-azaindole or from substituted amino-, iodo- or/and nit ropyridines using a catalysed palladium reaction or vicarious nucleophilic substitution of hydrogen (VNS) in order to elaborate the 6-, 5- and 4-azain dole derivatives respectively.