A global or European strategy should be developed to deal with increasing a
ntimicrobial resistance. This strategy includes surveillance of antimicrobi
al resistance and monitoring of the use of antimicrobial agents in animals
and humans. In animals, surveillance should be focussed on potential transf
er of resistant, zoonotic, food-born pathogens and resistance genes to huma
ns. In humans the surveillance should be clinically relevant. Guidelines fo
r rational therapy should be implemented and 'antibiotic teams' should be i
nstalled in each hospital to evaluate the prescription of antibiotics and i
ts compliance with guidelines. Keeping animals for food production involves
the responsibility for their well being. This includes treatment of infect
ions. However, the use of feed additive, growth-promoting antimicrobials re
lated to therapeutics in human medicine, should be banned immediately. Rese
arch aimed at intervention strategies for antimicrobial resistance should b
e given a high priority with adequate financing both nationally and in Euro
pe. Well co-ordinated European research programmes should have priority; th
is includes the need to install a European multidisciplinary scientific adv
isory group. (C) 1999 Published by Elsevier Science B.V. and International
Society of Chemotherapy. All rights reserved.