Genetic factors involved in cardiac calcification in STS/A and DBA/2 mouseinbred strains

The occurrence of juvenile dystrophic cardiac calcification (DCC) has been studied in an F2-intercross and backcross of DBA/2Ola and BALB/cOlaHsd mice and in CcS/Dem recombinant congenic strains (RCS) and their STS/A and BALB /cHeA parents. From the results of the F2-intercross and backcross it could be concluded that two to four genes are involved in the DCC susceptibility of the DBA/2Ola strain. Screening of the CcS recombinant congenic strains indicated that at least one of these genes is located on the proximal end o f Chromosome 7. This is in line with the results of IVANDIC et al. (1996) w ho have previously found evidence for a major gene (Dyscalc) on Chromosome 7.