Case report: Intra-abdominal angiosarcomatosis after radiotherapy

Background: We report a case of a 61-year-old Japanese woman who developed intra-abdominal angiosarcomatosis 20 years after receiving radiotherapy for squamous cell carcinoma of the cervix. Methods and Results: The surgically resected portion of the ileum showed di ffuse proliferating angiosarcoma, with irregular channels lined by atypical vascular endothelial cells. Immunohistochemical studies showed that the tu mour cells were positive for Factor VIII-related antigen and ulex europaeus agglutinin 1. At autopsy, the tumour had disseminated to the peritoneum an d invaded into the right thoracic cavity. Conclusions: These findings were compatible with radiation-induced angiosar comatosis.