Methoxymethylation of alcohols, phenols, and avermectin aglycones using MOM-2-pyridylsulfide

Authors
Marcune, BF Karady, S Dolling, UH Novak, TJ
Citation
Bf. Marcune et al., Methoxymethylation of alcohols, phenols, and avermectin aglycones using MOM-2-pyridylsulfide, J ORG CHEM, 64(7), 1999, pp. 2446-2449
Citations number
14
Categorie Soggetti
Chemistry & Analysis","Organic Chemistry/Polymer Science
Journal title
JOURNAL OF ORGANIC CHEMISTRY
ISSN journal
00223263 → ACNP
Volume
64
Issue
7
Year of publication
1999
Pages
2446 - 2449
Database
ISI
SICI code
0022-3263(19990402)64:7<2446:MOAPAA>2.0.ZU;2-O
Abstract
Methoxymethyl-2-pyridylsulfide (MOM-ON) is an effective methoxymethylating reagent when used in conjunction with AgOTf, NaOAc, and THF. A wide range o f MOM ethers are produced from corresponding phenols and alcohols, includin g tertiary and allylic alcohols, in good yields and under mild, neutral con ditions. This method is also effective for the methoxymethylation of averme ctin aglycones.