Analysis of the spatiotemporal EEG pattern in Alzheimer's disease

We present an analysis of the spatio-temporal EEG pattern in Alzheimer's di sease. The method of analysis, called the Karhunen-Loeve method, was applie d to 10 patients who were diagnosed as having Alzheimer's disease. The time -varying principal pattern of all 16 channels of the EEG pattern was observ ed. Compared with the controls the patients with Alzheimer's disease had si gnificantly different noticeable primary patterns and average values of the eigenvector component in 5 channels. i.e., Fp1, T3, C3, O1, and P3. These results can be considered to be due to a change in the relative diffusive a ctivity change of the brain corresponding to the Alzheimer's disease's path ologic variation in the brain and coincide with the results of previous stu dies.