Leukocytosis associated with and localized bladder cancer: Resolution withradiation therapy

Malignant tumors are occasionally associated with significant leukocytosis, (1) which is attributed to production of colony-stimulating factors.(2,3) B ladder carcinoma is rarely associated with paraneoplastic leukocytosis, whi ch is noted in the presence of metastatic disease and has been shown to res ult from autonomous production of granulocyte colony-stimulating factor by the tumor.(4,5) We report a case of localized transitional cell carcinoma o f the bladder with severe leukocytosis, which resolved with radiation treat ment of the tumor.